Implementing mixture survival model in R

[s***@gmail.com]

Dear R experts,
I am working on a project requiring to implement mixture survival model in R. Because we observe about 20% patients in our trial are living much longer than rest of the patients. I want to apply survival model with mixture distribution in order to estimate the fraction of those long survivors and also perform simulation to validate the mixture model.
I am wondering whether someone in this field can give me some help? Is there any R code that I can start with? I have tried survival package and flexsurv package. But didn't work out. I could not find a way to estimate the fraction parameter that I am interested.

Thanks very much!
Best regards,
Claire Xu

[David Duffy]

Post by s***@gmail.com
I am working on a project requiring to implement mixture survival
model in R. Because we observe about 20% patients in our trial are
living much longer than rest of the patients. I want to apply survival
model with mixture distribution in order to estimate the fraction of
those long survivors and also perform simulation to validate the mixture
model.
I am wondering whether someone in this field can give me some help? Is
there any R code that I can start with? I have tried survival package
and flexsurv package. But didn't work out.

Didn't work out??

Post by s***@gmail.com
I could not find a way to
estimate the fraction parameter that I am interested.

Sounds like you want a "cure" model. In R,

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494798/

and the bayesSurv package